Faculty, Staff and Student Publications
Language
English
Publication Date
4-1-2024
Journal
EJHaem
DOI
10.1002/jha2.855
PMID
38633116
PMCID
PMC11020126
PubMedCentral® Posted Date
2-21-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Myeloperoxidase (MPO) is the most specific marker of the myeloid lineage, essential for diagnosing acute myeloid leukemia and mixed phenotype acute leukemia with myeloid components. In this regard, we present a unique case of B-acute lymphoblastic leukemia (B-ALL) with isolated MPO expression in bone marrow blasts detected by flow cytometry and immunohistochemistry, while peripheral blood blasts were negative for MPO expression. In this report, our discussion encompasses diagnostic pitfalls from a laboratory testing perspective in similar cases and includes a literature review. Furthermore, we emphasize the necessity of conducting a comprehensive analysis for the accurate diagnosis of MPO-positive B-ALL cases.
Keywords
acute myeloid leukemia, B‐lymphoblastic leukemia, bone marrow, flow cytometry, myeloperoxidase, peripheral blood
Published Open-Access
yes
Recommended Citation
Wang, Wei J; Gehris, Brandon T; Rivera, Daniel; et al., "Bone Marrow-Restricted Aberrant Myeloperoxidase Expression in B-Acute Lymphoblastic Leukemia: A Diagnostic Dilemma and Mimicry of Mixed Phenotype Acute Leukemia" (2024). Faculty, Staff and Student Publications. 6691.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6691
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