Leukemic Phase Follicular Lymphoma in a Young Adult

Authors

Daniel Rivera
Wei Wang
Zubaidah Al-Jumaili
Zhihong Hu

Language

English

Publication Date

3-1-2023

Journal

Journal of Clinical Laboratory Analysis

DOI

10.1002/jcla.24869

PMID

36930792

PMCID

PMC10098048

PubMedCentral® Posted Date

3-17-2023

PubMedCentral® Full Text Version

Post-print

Abstract

Background: Leukemic presentation of follicular lymphoma (FL) is uncommon, with most cases reported in older adults.

Design: This report describes an unusual case of a young adult diagnosed with leukemic phase of FL. We reviewed the existing literature on this rare presentation of the disease and its potential impact on patient outcomes.

Results: Leukemic phase of FL in young adults can be mistaken for other high-grade hematologic malignancies. Morphology assessment and ancillary testing, such as flow cytometry and FISH analysis, can assist in achieving an accurate diagnosis of the leukemic phase of FL. Notably, our young patient responded well to therapy, which is different from what is typically observed in older patients who have a poorer prognosis. Further cases are needed to investigate the prognostic impact of the leukemic phase of FL in younger patients.

Keywords

Humans, Lymphoma, Follicular, Prognosis, In Situ Hybridization, Fluorescence, Proto-Oncogene Proteins c-bcl-2, BCL2 rearrangement, follicular lymphoma, leukemic phase, lymphocytosis

Published Open-Access

yes

Recommended Citation

Rivera, Daniel; Wang, Wei; Al-Jumaili, Zubaidah; et al., "Leukemic Phase Follicular Lymphoma in a Young Adult" (2023). Faculty, Staff and Student Publications. 6699.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6699