Flow Cytometry Profiling of Plasmacytoid Dendritic Cell Neoplasms

Authors

Siba El Hussein
Wei Wang

Language

English

Publication Date

6-1-2024

Journal

Cancers

DOI

10.3390/cancers16112118

PMID

38893237

PMCID

PMC11171351

PubMedCentral® Posted Date

6-1-2024

PubMedCentral® Full Text Version

Post-print

Abstract

In this review, we aim to provide a summary of the diverse immunophenotypic presentations of distinct entities associated with plasmacytoid dendritic cell (pDC) proliferation. These entities include the following: (1) blastic plasmacytoid dendritic cell neoplasm (BPDCN); (2) mature pDC proliferation (MPDCP), most commonly seen in chronic myelomonocytic leukemia (CMML); and (3) myeloid neoplasms with pDC differentiation, in which pDCs show a spectrum of maturation from early immature pDCs to mature forms, most commonly seen in acute myeloid leukemia (pDC-AML). Our aim is to provide a flow cytometry diagnostic approach to these distinct and sometimes challenging entities and to clarify the immunophenotypic spectrum of neoplastic pDCs in different disease presentations. In this review, we also cover the strategies in the evaluation of residual disease, as well as the challenges and pitfalls we face in the setting of immune and targeted therapy. The differential diagnosis will also be discussed, as blasts in some AML cases can have a pDC-like immunophenotype, mimicking pDCs.

Keywords

flow cytometry analysis, plasmacytoid dendritic cells, blastic plasmacytoid dendritic cell neoplasm, BPDCN, mature plasmacytoid dendritic cell proliferation, MPDCP, AML with plasmacytoid dendritic cell differentiation, pDC-AML

Published Open-Access

yes

Recommended Citation

Siba El Hussein and Wei Wang, "Flow Cytometry Profiling of Plasmacytoid Dendritic Cell Neoplasms" (2024). Faculty, Staff and Student Publications. 6706.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6706