Faculty, Staff and Student Publications

Language

English

Publication Date

11-30-2024

Journal

Molecular Cancer

DOI

10.1186/s12943-024-02183-9

PMID

39614288

PMCID

PMC11607834

PubMedCentral® Posted Date

11-30-2024

PubMedCentral® Full Text Version

Post-print

Abstract

In the realm of cancer research, the tumor microenvironment (TME) plays a crucial role in tumor initiation and progression, shaped by complex interactions between cancer cells and surrounding non-cancerous cells. Cytokines, as essential immunomodulatory agents, are secreted by various cellular constituents within the TME, including immune cells, cancer-associated fibroblasts, and cancer cells themselves. These cytokines facilitate intricate communication networks that significantly influence tumor initiation, progression, metastasis, and immune suppression. Pyroptosis contributes to TME remodeling by promoting the release of pro-inflammatory cytokines and sustaining chronic inflammation, impacting processes such as immune escape and angiogenesis. However, challenges remain due to the complex interplay among cytokines, pyroptosis, and the TME, along with the dual effects of pyroptosis on cancer progression and therapy-related complications like cytokine release syndrome. Unraveling these complexities could facilitate strategies that balance inflammatory responses while minimizing tissue damage during therapy. This review delves into the complex crosstalk between cytokines, pyroptosis, and the TME, elucidating their contribution to tumor progression and metastasis. By synthesizing emerging therapeutic targets and innovative technologies concerning TME, this review aims to provide novel insights that could enhance treatment outcomes for cancer patients.

Keywords

Humans, Pyroptosis, Tumor Microenvironment, Neoplasms, Cytokines, Animalsm, Pyroptosis, Cytokine, Tumor microenvironment, Mechanism, Clinical implication

Published Open-Access

yes

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