Faculty, Staff and Student Publications
Language
English
Publication Date
11-1-2024
Journal
Current Oncology Reports
DOI
10.1007/s11912-024-01603-9
PMID
39361076
PMCID
PMC11793993
PubMedCentral® Posted Date
11-1-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Purpose of review: This review aims to synthesize available literature on uterine-conserving treatment options for atypical endometrial hyperplasia and grade 1 endometrial carcinoma while highlighting remaining unanswered questions.
Recent findings: The need for uterine-conserving treatment options for atypical endometrial hyperplasia and grade 1 endometrial carcinoma is growing with the increasing number of cases in younger patients or those who cannot undergo surgery. We reviewed the oncological and reproductive outcomes associated with endocrine therapies used for atypical endometrial hyperplasia and grade 1 endometrial carcinoma. The rising prevalence of delayed childbearing, obesity, and diabetes in reproductive-age individuals and of medical comorbidities associated with high surgical risk continues to amplify the demand for uterine-conserving therapies. Appropriate patient selection for such therapies is imperative to maximize likelihood of treatment response. The ideal candidates are patients with atypical endometrial hyperplasia or early-stage, low-grade endometrial cancer with no evidence of myometrial invasion or extrauterine disease. The most accepted conservative therapeutic approach is hormonal therapy with close surveillance, with or without eventual hysterectomy following childbearing or failure of treatment. Further prospective and randomized trials are needed to address optimal patient and treatment selection, as well as the use of molecular profiling for treatment individualization and prognostication.
Keywords
Humans, Female, Endometrial Neoplasms, Endometrial Hyperplasia, Hysterectomy, endometrial cancer, atypical endometrial hyperplasia, uterine conservation, fertility-sparing, uterine cancer, progesterone therapy
Published Open-Access
yes
Recommended Citation
Adjei, Naomi N; Bowen, Mikayla Borthwick; Wilke, Roni Nitecki; et al., "Uterine-Conserving Treatment Options for Atypical Endometrial Hyperplasia and Early Endometrial Cancer" (2024). Faculty, Staff and Student Publications. 6770.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6770
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