Proteome-Wide Association Study of Prostate Cancer Risk Across Populations

Authors

• Hua Zhong
• Jingjing Zhu
• Shuai Liu
• Chong Wu
• Liang Wang
• Seamus P Whelton
• Catherine H Marshall
• Michael J Blaha
• Peter Durda
• Xiuqing Guo
• Craig W Johnson
• Henry J Lin
• Kent D Taylor
• Russell P Tracy
• Ronit I Yarden
• Ani W Manichaikul
• Stephen S Rich
• Jerome I Rotter
• Rajat Deo
• Ruth F Dubin
• Peter Ganz
• Lang Wu

Language

English

Publication Date

12-6-2025

Journal

Nature Communications

DOI

10.1038/s41467-025-66250-5

PMID

41353205

PMCID

PMC13039972

PubMedCentral® Posted Date

12-6-2025

PubMedCentral® Full Text Version

Post-print

Abstract

There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in plasma to be associated with PCa risk across populations. We develop genetic prediction models for expression of 1578, 1993, 1218, and 1390 proteins for African (n = 450), European (n = 758), Asian (n = 289), and Hispanic/Latino (n = 474) males, respectively, and evaluate associations of genetically regulated protein expression with PCa risk in 19,391 PCa cases and 61,608 controls of African population, 122,188 cases and 604,640 controls of European population, 10,809 cases and 95,790 controls of Asian population, and 3931 cases and 26,405 controls of Hispanic/Latino population. We identify three, four, 15, and 73 PCa-associated proteins in African, Hispanic/Latino, Asian, and European populations, respectively, and 83 in trans-population meta-analysis. There are both pan-population and population-specific associations. Our findings provide valuable insights into etiology of PCa.

Keywords

Humans, Male, Prostatic Neoplasms, Proteome, Genome-Wide Association Study, White People, Genetic Predisposition to Disease, Case-Control Studies, Risk Factors, Middle Aged, Hispanic or Latino, Asian People, Aged, Black People, White, Cancer genetics, Cancer epidemiology, Prostate cancer

Published Open-Access

yes

Recommended Citation

Zhong, Hua; Zhu, Jingjing; Liu, Shuai; et al., "Proteome-Wide Association Study of Prostate Cancer Risk Across Populations" (2025). Faculty, Staff and Student Publications. 6803.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/6803