Faculty, Staff and Student Publications
Publication Date
2-28-2023
Journal
Cell Reports
DOI
10.1016/j.celrep.2023.112040
PMID
36701231
PMCID
PMC10366340
PubMedCentral® Posted Date
October 2023
PubMedCentral® Full Text Version
Author MSS
Abstract
Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer immunotherapy target in mice, its potential to cause toxicity, specific mode of action with regard to its cellular targets, and whether it can be targeted in humans remain unknown. Here, we show that JAML is induced by T cell receptor engagement, reveal that this induction is linked to cis-regulatory interactions between the CD3D and JAML gene loci. When compared with other immunotherapy targets plagued by low target specificity and end-organ toxicity, we find JAML to be mostly restricted to and highly expressed by tissue-resident memory CD8
Keywords
Humans, Animals, Mice, Junctional Adhesion Molecules, Cell Adhesion Molecules, CD8-Positive T-Lymphocytes, Neoplasms, Immunotherapy, Lymphocytes, Tumor-Infiltrating
Published Open-Access
yes
Recommended Citation
Eschweiler, Simon; Wang, Alice; Ramírez-Suástegui, Ciro; et al., "JAML Immunotherapy Targets Recently Activated Tumor-Infiltrating CD8+ T Cells" (2023). Faculty, Staff and Student Publications. 682.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/682
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