Faculty, Staff and Student Publications

Language

English

Publication Date

4-1-2026

Journal

Journal of Biomolecular Structure and Dynamics

DOI

10.1080/07391102.2025.2474683

PMID

40091796

PMCID

PMC12353482

Abstract

Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal CAG expansion in the Huntingtin (HTT) gene. Given its simple genetic cause but complex pathogenic mechanisms, interest in targeting HTT for HD treatment is growing, necessitating a clear understanding of HTT regulation. HTT protein primarily exists in a core complex with HAP40, forming a highly ordered structure with two large globular domains connected by a bridge. We previously demonstrated that HAP40 is conserved in

Keywords

Animals, Humans, Huntingtin Protein, Drosophila Proteins, Protein Binding, Huntington Disease, Molecular Dynamics Simulation, Models, Molecular, Drosophila, Structure-Activity Relationship, Drosophila melanogaster, Amino Acid Sequence

Published Open-Access

yes

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