Daily Fosfomycin Versus Levofloxacin for Complicated Urinary Tract Infections

Authors

Nadine Rouphael
Patricia Winokur
Michael C Keefer
Jessica Traenkner
Ana Drobeniuc
Yohei Doi
Sonal Munsiff
Vance G Fowler
Scott Evans
Randolph E Oler
Bonifride Tuyishimire
Marina Lee
Varduhi Ghazaryan
Henry F Chambers

Publication Date

10-31-2023

Journal

mBio

Abstract

Concerns over resistance and safety have been identified in the current treatment regimen for complicated urinary tract infections. Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.

Keywords

Humans, Fosfomycin, Levofloxacin, Urinary Tract Infections, Anti-Bacterial Agents, Cystitis, complicated UTI, fosfomycin, oral antibiotic

DOI

10.1128/mbio.01677-23

PMID

37698412

PMCID

PMC10783529

PubMedCentral® Posted Date

September 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes