A Facile Synthetic Method for Anhydride from Carboxylic Acid with the Promotion of Triphenylphosphine Oxide and Oxaloyl Chloride

Authors

Mengyu Lu
Huihui Fan
Qing Liu
Xiaoling Sun

Publication Date

9-27-2022

Journal

ACS Omega

Abstract

A highly efficient synthesis reaction of carboxylic anhydrides catalyzed by triphenylphosphine oxide is described for the quick synthesis of a range of symmetric carboxylic anhydrides and cyclic anhydrides under mild and neutral conditions with a high yield. The system adopts the strong reactive intermediate Ph3PCl2 as the catalyst of carboxylic acid salt; driven by catalytic reaction, the synthesis takes a relatively short time to complete.

DOI

10.1021/acsomega.2c03991

PMID

36188305

PMCID

PMC9520564

PubMedCentral® Posted Date

September 2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes