Faculty, Staff and Student Publications

Publication Date

4-1-2023

Journal

British Journal of Cancer

Abstract

BACKGROUND: Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.

METHODS: We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method.

RESULTS: Of 450,105 participants (318,680 women) followed for 14.2 ± 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HR

CONCLUSIONS: Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources.

Keywords

Male, Humans, Female, Heme, Prospective Studies, Cohort Studies, Risk Factors, Diet, Eating, Colorectal Neoplasms, Iron

DOI

10.1038/s41416-023-02164-7

PMID

36759722

PMCID

PMC10070394

PubMedCentral® Posted Date

February 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes

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