Faculty, Staff and Student Publications
Publication Date
1-11-2023
Journal
Cells
Abstract
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.
Keywords
CAMKK2, kinase, chemical probe, NanoBRET, kinase selectivity
DOI
10.3390/cells12020287
PMID
36672221
PMCID
PMC9856672
PubMedCentral® Posted Date
January 2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Bioinformatics Commons, Biomedical Informatics Commons, Medical Biochemistry Commons, Oncology Commons
Comments
Supplementary Material
PMID: 36672221