Faculty, Staff and Student Publications
Publication Date
5-30-2023
Journal
Cell Reports
DOI
10.1016/j.celrep.2023.112529
PMID
37200193
PMCID
PMC10312392
PubMedCentral® Posted Date
June 2023
PubMedCentral® Full Text Version
Author MSS
Abstract
Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide-1 (GLP-1) insulinotropic action. Here, we examined the architecture of AR targets that regulate GLP-1 insulinotropic action in male β cells. Testosterone cooperates with GLP-1 to enhance cAMP production at the plasma membrane and endosomes via: (1) increased mitochondrial production of CO
Keywords
Male, Mice, Humans, Animals, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Adenylyl Cyclases, Receptors, Androgen, Insulin, Glucose, Testosterone, Islets of Langerhans, Peptide Fragments, Mammals
Published Open-Access
yes
Recommended Citation
Xu, Weiwei; Qadir, M M Fahd; Nasteska, Daniela; et al., "Architecture of Androgen Receptor Pathways Amplifying Glucagon-Like Peptide-1 Insulinotropic Action in Male Pancreatic β Cells" (2023). Faculty, Staff and Student Publications. 758.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/758
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