Faculty, Staff and Student Publications
Publication Date
5-30-2023
Journal
Cell Reports
Abstract
Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide-1 (GLP-1) insulinotropic action. Here, we examined the architecture of AR targets that regulate GLP-1 insulinotropic action in male β cells. Testosterone cooperates with GLP-1 to enhance cAMP production at the plasma membrane and endosomes via: (1) increased mitochondrial production of CO
Keywords
Male, Mice, Humans, Animals, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Adenylyl Cyclases, Receptors, Androgen, Insulin, Glucose, Testosterone, Islets of Langerhans, Peptide Fragments, Mammals
DOI
10.1016/j.celrep.2023.112529
PMID
37200193
PMCID
PMC10312392
PubMedCentral® Posted Date
June 2023
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons
Comments
Supplementary Material
PMID: 37200193