Student and Faculty Publications
Publication Date
5-30-2023
Journal
Cell Reports
Abstract
Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide-1 (GLP-1) insulinotropic action. Here, we examined the architecture of AR targets that regulate GLP-1 insulinotropic action in male β cells. Testosterone cooperates with GLP-1 to enhance cAMP production at the plasma membrane and endosomes via: (1) increased mitochondrial production of CO
Keywords
Male, Mice, Humans, Animals, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Adenylyl Cyclases, Receptors, Androgen, Insulin, Glucose, Testosterone, Islets of Langerhans, Peptide Fragments, Mammals
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons
Comments
Supplementary Materials
PMID: 37200193