Hyperoxidized PRDX3 as a Specific Ferroptosis Marker

Authors

Yuelong Yan
Boyi Gan

Publication Date

12-1-2023

Journal

Life Metabolism

Abstract

The lack of a reliable and specific marker for ferroptosis has hindered the advancement of treatments related to this cell death mechanism toward clinical application. A recent study published in Molecular Cell has identified hyperoxidized peroxiredoxin 3 (PRDX3) as a promising marker for ferroptosis, opening up new avenues for monitoring and targeting ferroptosis in disease treatment.

Keywords

Ferroptosis, biomarker, PRDX3, hyperoxidation, lipid peroxidation

Comments

NIHMSID: NIHMS1948572

DOI

10.1093/lifemeta/load042

PMID

38179338

PMCID

PMC10766428

PubMedCentral® Posted Date

November 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes