A Time and Place for Inhibiting Autophagy

Authors

Boyi Gan

Publication Date

12-2-2022

Journal

Cancer Research

Abstract

Autophagy is an attractive therapeutic target in cancer. Successful autophagy-focused clinical intervention will require a detailed understanding of when and where autophagy is important during tumorigenesis. In this issue of Cancer Research, Khayati and colleagues use state-of-the-art genetically engineered mouse models to demonstrate that transient systemic inhibition of autophagy can irreversibly impair the growth of established lung tumors with a good tolerability in normal tissues, suggesting a therapeutic strategy for cancer treatment.

Keywords

Animals, Mice, Immunotherapy, Lung Neoplasms, Autophagy, Carcinogenesis, Cell Transformation, Neoplastic

Comments

PMID: 36458406

DOI

10.1158/0008-5472.CAN-22-3024

PMID

36458406

PMCID

PMC9720714

PubMedCentral® Posted Date

June 2023

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes