From Disorder Comes Function: Regulation of Small GTPase Function by Intrinsically Disordered Lipidated Membrane Anchor

Authors

Chase M Hutchins
Alemayehu A Gorfe

Publication Date

8-1-2024

Journal

Current Opinion in Structural Biology

Abstract

The intrinsically disordered, lipid-modified membrane anchor of small GTPases is emerging as a critical modulator of function through its ability to sort lipids in a conformation-dependent manner. We reviewed recent computational and experimental studies that have begun to shed light on the sequence-ensemble-function relationship in this unique class of lipidated intrinsically disordered regions (LIDRs).

Keywords

Small GTPases, intrinsically disordered region (IDR), lipidated IDR, intrinsically disordered protein (IDP)

Comments

PMID: 38943706

DOI

10.1016/j.sbi.2024.102869

PMID

38943706

PMCID

PMC11283958

PubMedCentral® Posted Date

August 2024

PubMedCentral® Full Text Version

Author MSS

Published Open-Access

yes