Faculty, Staff and Student Publications
Publication Date
8-1-2024
Journal
Current Opinion in Structural Biology
Abstract
The intrinsically disordered, lipid-modified membrane anchor of small GTPases is emerging as a critical modulator of function through its ability to sort lipids in a conformation-dependent manner. We reviewed recent computational and experimental studies that have begun to shed light on the sequence-ensemble-function relationship in this unique class of lipidated intrinsically disordered regions (LIDRs).
Keywords
Small GTPases, intrinsically disordered region (IDR), lipidated IDR, intrinsically disordered protein (IDP)
DOI
10.1016/j.sbi.2024.102869
PMID
38943706
PMCID
PMC11283958
PubMedCentral® Posted Date
August 2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes
Included in
Bioinformatics Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Biomedical Informatics Commons, Medical Specialties Commons
