Faculty, Staff and Student Publications
Publication Date
8-1-2024
Journal
Current Opinion in Structural Biology
DOI
10.1016/j.sbi.2024.102869
PMID
38943706
PMCID
PMC11283958
PubMedCentral® Posted Date
August 2024
PubMedCentral® Full Text Version
Author MSS
Abstract
The intrinsically disordered, lipid-modified membrane anchor of small GTPases is emerging as a critical modulator of function through its ability to sort lipids in a conformation-dependent manner. We reviewed recent computational and experimental studies that have begun to shed light on the sequence-ensemble-function relationship in this unique class of lipidated intrinsically disordered regions (LIDRs).
Keywords
Small GTPases, intrinsically disordered region (IDR), lipidated IDR, intrinsically disordered protein (IDP)
Published Open-Access
yes
Recommended Citation
Chase M Hutchins and Alemayehu A Gorfe, "From Disorder Comes Function: Regulation of Small GTPase Function by Intrinsically Disordered Lipidated Membrane Anchor" (2024). Faculty, Staff and Student Publications. 917.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/917
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