Differential Effects of Bariatric Surgery and Caloric Restriction on Hepatic One-Carbon and Fatty Acid Metabolism

Authors

Arnon Haran
Michael Bergel
Doron Kleiman
Liron Hefetz
Hadar Israeli
Sarah Weksler-Zangen
Bella Agranovich
Ifat Abramovich
Rachel Ben-Haroush Schyr
Eyal Gottlieb
Danny Ben-Zvi

Publication Date

7-21-2023

Journal

iScience

Abstract

Weight loss interventions, including dietary changes, pharmacotherapy, or bariatric surgery, prevent many of the adverse consequences of obesity, and may also confer intervention-specific benefits beyond those seen with decreased weight alone. We compared the molecular effects of different interventions on liver metabolism to understand the mechanisms underlying these benefits. Male rats on a high-fat, high-sucrose diet underwent sleeve gastrectomy (SG) or intermittent fasting with caloric restriction (IF-CR), achieving equivalent weight loss. The interventions were compared to

Keywords

Surgery, Omics

Comments

Supplementary Material

PMID: 37389181

DOI

10.1016/j.isci.2023.107046

PMID

37389181

PMCID

PMC10300224

PubMedCentral® Posted Date

June 2023

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes