Faculty, Staff and Student Publications
Publication Date
7-1-2023
Journal
Progress in Retinal and Eye Research
Abstract
Wnt signaling comprises a group of complex signal transduction pathways that play critical roles in cell proliferation, differentiation, and apoptosis during development, as well as in stem cell maintenance and adult tissue homeostasis. Wnt pathways are classified into two major groups, canonical (β-catenin-dependent) or non-canonical (β-catenin-independent). Most previous studies in the eye have focused on canonical Wnt signaling, and the role of non-canonical signaling remains poorly understood. Additionally, the crosstalk between canonical and non-canonical Wnt signaling in the eye has hardly been explored. In this review, we present an overview of available data on ocular non-canonical Wnt signaling, including developmental and functional aspects in different eye compartments. We also discuss important changes of this signaling in various ocular conditions, such as keratoconus, aniridia-related keratopathy, diabetes, age-related macular degeneration, optic nerve damage, pathological angiogenesis, and abnormalities in the trabecular meshwork and conjunctival cells, and limbal stem cell deficiency.
Keywords
Planar cell polarity, calcium signaling, Wnt signaling, eye development, eye diseases, cornea, retina, lens, conjunctiva, stem cells
DOI
10.1016/j.preteyeres.2022.101149
PMID
36443219
PMCID
PMC10209355
PubMedCentral® Posted Date
July 2024
PubMedCentral® Full Text Version
Author MSS
Published Open-Access
yes