A Retrospective Genomic Landscape of 661 Young Adult Glioblastomas Diagnosed Using 2016 WHO Guidelines for Central Nervous System Tumors

Authors

James F Haberberger
Worthy Pegram
Nicholas Britt
Kelsie Schiavone
Eric Severson
Radwa Sharaf
Lee A Albacker
Erik Williams
Mirna Lechpammer
Amanda Hemmerich
Douglas Lin
Richard S P Huang
Matthew Hiemenz
Julia Elvin
Ryon Graf
Glenn Lesser
David Kram
Roy Strowd
Wenya Linda Bi
Lori A Ramkissoon
Michael B Cohen
Prasanth Reddy
James Creeden
Jeffrey S Ross
Brian M Alexander
Shakti H Ramkissoon

Publication Date

1-5-2024

Journal

The Oncologist

Abstract

The authors present a cohort of 661 young adult glioblastomas diagnosed using 2016 WHO World Health Organization Classification of Tumors of the Central Nervous System, utilizing comprehensive genomic profiling (CGP) to explore their genomic landscape and assess their relationship to currently defined disease entities. This analysis explored variants with evidence of pathogenic function, common copy number variants (CNVs), and several novel fusion events not described in literature. Tumor mutational burden (TMB) mutational signatures, anatomic location, and tumor recurrence are further explored. Using data collected from CGP, unsupervised machine-learning techniques were leveraged to identify 10 genomic classes in previously assigned young adult glioblastomas. The authors relate these molecular classes to current World Health Organization guidelines and reference current literature to give therapeutic and prognostic descriptions where possible.

Keywords

Humans, Young Adult, Glioblastoma, Retrospective Studies, Mutation, Neoplasm Recurrence, Local, Central Nervous System Neoplasms, Genomics, brain cancer, central nervous system, glioblastoma, next-generation sequencing

Comments

Supplementary Materials

PMID: 37619245