Syphilis Complicating Pregnancy and Congenital Syphilis. Reply

Authors

• Irene A Stafford
• Kimberly A Workowski
• Laura H Bachmann

Language

English

Publication Date

4-4-2024

Journal

The New England Journal of Medicine

DOI

10.1056/NEJMc2401932

PMID

38598599

PMCID

PMC11809929

PubMedCentral® Posted Date

2-10-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

The authors reply: The Jarisch–Herxheimer reaction is an underreported and often-over-looked sequela of antimicrobial therapy in persons with spirochetal disease and is caused by the release of treponemal constituents.1 Sandoval’s description of the clinical manifestations of this reaction is an important reminder for clinicians to recognize the reaction and avoid the pitfalls of incorrectly diagnosing it as an allergic reaction to penicillin; it also highlights a critical aspect of care for persons with syphilis, including neonates with congenital syphilis.

Keywords

Pregnancy, Female, Humans, Syphilis, Congenital, Syphilis, Pregnancy Complications, Infectious

Published Open-Access

yes

Recommended Citation

Irene A Stafford, Kimberly A Workowski, and Laura H Bachmann, "Syphilis Complicating Pregnancy and Congenital Syphilis. Reply" (2024). Faculty, Staff and Student Publications. 3920.
https://digitalcommons.library.tmc.edu/uthmed_docs/3920