Faculty, Staff and Student Publications
Language
English
Publication Date
4-6-2024
Journal
Pediatric Surgery International
DOI
10.1007/s00383-024-05674-4
PMID
38581576
Abstract
Purpose: The effect of different types of lipid emulsion may guide therapy of patients with intestinal failure (IF) to limit morbidity such as intestinal failure-associated liver disease (IFALD).
Methods: A retrospective chart review of pediatric patients with IF who received soybean oil lipid emulsion (SL) or mixed oil lipid emulsion (ML) was performed. Data over 1 year were collected.
Results: Forty-five patients received SL and 34 received ML. There were no differences in the incidence (82 versus 74%, P = 0.35) or resolution (86 versus 92%, P = 0.5) of IFALD between the cohorts. The median dose of ML was higher compared to SL (2 versus 1 g/kg/day, P < 0.001). If resolved, IFALD resolved rapidly in the ML cohort compared to the SL cohort (67 versus 37 days, P = 0.01). Weight gain was higher in the ML compared to the SL cohort at resolution of IFALD or 1 year from diagnosis of IF (P = 0.009).
Conclusion: The administration of ML did not alter the incidence or resolution of IFALD compared to SL in pediatric IF. There was rapid resolution of IFALD and enhanced weight gain in the ML cohort compared to SL in pediatric IF.
Keywords
Humans, Child, Fat Emulsions, Intravenous, Parenteral Nutrition, Intestinal Failure, Retrospective Studies, Intestinal Diseases, Liver Diseases, Liver Failure, Soybean Oil, Weight Gain, Fish Oils, Intestinal failure-associated liver disease, Mixed oil lipid emulsion, Parenteral nutrition, Soybean oil lipid emulsion
Published Open-Access
yes
Recommended Citation
Naik, Mamta; Lawrence, Alexandria; Davidson, Allison; et al., "Comparison of Two Formulations of Intravenous Lipid Emulsions in Pediatric Intestinal Failure" (2024). Faculty, Staff and Student Publications. 4144.
https://digitalcommons.library.tmc.edu/uthmed_docs/4144