Apoptotic Brown Adipocytes Enhance Energy Expenditure Via Extracellular Inosine

Authors

Birte Niemann
Saskia Haufs-Brusberg
Laura Puetz
Martin Feickert
Michelle Y Jaeckstein
Anne Hoffmann
Jelena Zurkovic
Markus Heine
Eva-Maria Trautmann
Christa E Müller
Anke Tönjes
Christian Schlein
Azin Jafari
Holger K Eltzschig
Thorsten Gnad
Matthias Blüher
Natalie Krahmer
Peter Kovacs
Joerg Heeren
Alexander Pfeifer

Publication Date

9-1-2022

Journal

Nature

Abstract

Brown adipose tissue (BAT) dissipates energy

Keywords

Adipocytes, Brown, Adipose Tissue, Brown, Adipose Tissue, White, Animals, Energy Metabolism, Equilibrative Nucleoside Transporter 1, Humans, Inosine, Mice, Obesity, Thermogenesis, Uncoupling Protein 1

DOI

10.1038/s41586-022-05041-0

PMID

35790189

PMCID

PMC9452294

PubMedCentral® Posted Date

July 2022

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes