Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System

Authors

Fabio N Gava
Alexandre A da Silva
Xuemei Dai
Romain Harmancey
Sadia Ashraf
Ana C M Omoto
Mateus C Salgado
Sydney P Moak
Xuan Li
John E Hall
Jussara M do Carmo

Publication Date

1-1-2021

Journal

JACC: Basic to Translational Science

Abstract

Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, Ca

Keywords

AMPK, adenosine monophosphate–activated protein kinase; BP, blood pressure; CNS, central nervous system; HF, heart failure; HR, heart rate; ICV, intracerebroventricular; LV, left ventricular; MC4R; MC4R, melanocortin-4 receptor; MI, myocardial infarction; MTII, melanotan II; appetite; blood pressure; cardiac metabolism; heart failure; mTOR, mechanistic target of rapamycin