Publication Date
1-1-2021
Journal
JACC: Basic to Translational Science
Abstract
Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, Ca
Keywords
appetite, blood pressure, cardiac metabolism, heart failure, MC4R