Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System

Authors

Fabio N Gava
Alexandre A da Silva
Xuemei Dai
Romain Harmancey
Sadia Ashraf
Ana C M Omoto
Mateus C Salgado
Sydney P Moak
Xuan Li
John E Hall
Jussara M do Carmo

Publication Date

1-1-2021

Journal

JACC: Basic to Translational Science

Abstract

Heart failure has a high mortality rate, and current therapies offer limited benefits. The authors demonstrate that activation of the central nervous system leptin-melanocortin pathway confers remarkable protection against progressive heart failure following severe myocardial infarction. The beneficial cardiac-protective actions of leptin require activation of brain melanocortin-4 receptors and elicit improvements in cardiac substrate oxidation, cardiomyocyte contractility, Ca

Keywords

AMPK, adenosine monophosphate–activated protein kinase, BP, blood pressure, CNS, central nervous system, HF, heart failure, HR, heart rate, ICV, intracerebroventricular, LV, left ventricular, MC4R, MC4R, melanocortin-4 receptor, MI, myocardial infarction, MTII, appetite, blood pressure, cardiac metabolism, heart failure, MC4Rmelanotan II, appetite, blood pressure, cardiac metabolism, heart failure, mTOR, mechanistic target of rapamycin

DOI

10.1016/j.jacbts.2020.11.007

PMID

33532666

PMCID

PMC7838051

PubMedCentral® Posted Date

February 2021

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes