Faculty, Staff and Student Publications
Publication Date
5-1-2024
Journal
British Journal of Cancer
Abstract
BACKGROUND: We characterized age at diagnosis and estimated sex differences for lung cancer and its histological subtypes among individuals who never smoke.
METHODS: We analyzed the distribution of age at lung cancer diagnosis in 33,793 individuals across 8 cohort studies and two national registries from East Asia, the United States (US) and the United Kingdom (UK). Student's t-tests were used to assess the study population differences (Δ years) in age at diagnosis comparing females and males who never smoke across subgroups defined by race/ethnicity, geographic location, and histological subtypes.
RESULTS: We found that among Chinese individuals diagnosed with lung cancer who never smoke, females were diagnosed with lung cancer younger than males in the Taiwan Cancer Registry (n = 29,832) (Δ years = -2.2 (95% confidence interval (CI):-2.5, -1.9), in Shanghai (n = 1049) (Δ years = -1.6 (95% CI:-2.9, -0.3), and in Sutter Health and Kaiser Permanente Hawai'i in the US (n = 82) (Δ years = -11.3 (95% CI: -17.7, -4.9). While there was a suggestion of similar patterns in African American and non-Hispanic White individuals. the estimated differences were not consistent across studies and were not statistically significant.
CONCLUSIONS: We found evidence of sex differences for age at lung cancer diagnosis among individuals who never smoke.
Keywords
Humans, Male, Female, United States, Ethnicity, Smoke, Lung Neoplasms, China, White
DOI
10.1038/s41416-024-02592-z
PMID
38388856
PMCID
PMC11014844
PubMedCentral® Posted Date
February 2024
PubMedCentral® Full Text Version
Post-Print
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Biomedical Informatics Commons, Diseases Commons, Gender and Sexuality Commons, Oncology Commons, Pulmonology Commons, Race and Ethnicity Commons
Comments
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