Faculty, Staff and Student Publications
Language
English
Publication Date
5-1-2024
Journal
Advanced Science
DOI
10.1002/advs.202308124
PMID
38520726
PMCID
PMC11132069
PubMedCentral® Posted Date
March 2024
PubMedCentral® Full Text Version
Post-Print
Abstract
Cancer immunotherapy is an attractive strategy because it stimulates immune cells to target malignant cells by regulating the intrinsic activity of the immune system. However, due to lacking many immunologic markers, it remains difficult to treat glioma, a representative "cold" tumor. Herein, to wake the "hot" tumor immunity of glioma, Porphyromonas gingivalis (Pg) is customized with a coating to create an immunogenic tumor microenvironment and further prove the effect in combination with the immune checkpoint agent anti-PD-1, exhibiting elevated therapeutic efficacy. This is accomplished not by enhancing the delivery of PD-1 blockade to enhance the effect of immunotherapy, but by introducing bacterial photothermal therapy to promote greater involvement of M1 cells in the immune response. After reaching glioma, the bacteria further target glioma cells and M2 phenotype macrophages selectively, enabling precise photothermal conversion for lysing tumor cells and M2 phenotype macrophages, which thereby enhances the positive feedback loop of cancer cells-M1 macrophages-T cells. Collectively, the bacteria synergized with PD-1 blockade strategy may be the key to overcoming the immunosuppressive glioma microenvironment and improving the outcome of immunotherapy toward glioma.
Keywords
anti‐PD‐1, cancer immunotherapy, customized bacteria, glioma, tumor microenvironment
Published Open-Access
yes
Recommended Citation
Chen, Qi; Zheng, Yuyi; Chen, Xiaojie; et al., "Bacteria Synergized With Pd-1 Blockade Enhance Positive Feedback Loop of Cancer Cells-M1 Macrophages-T Cells In Glioma" (2024). Faculty, Staff and Student Publications. 365.
https://digitalcommons.library.tmc.edu/uthshis_docs/365