Faculty, Staff and Student Publications

Language

English

Publication Date

6-15-2026

Journal

Alzheimer's Research & Therapy

DOI

10.1186/s13195-026-02100-w

PMID

42298651

Abstract

Introduction: List-learning tasks (LLTs) are important for characterizing memory in Alzheimer's disease and related dementias. However, as the Uniform Data Set Neuropsychological Battery (UDS-NB) historically did not require a specific LLT, centers have administered different LLTs. The newest UDS version (v4.0) requires one of two LLTs. To support harmonized UDS memory research, we developed a memory composite incorporating UDS memory tests and multiple LLTs.

Methods: Item-banking confirmatory factor analysis was applied to develop a memory composite in a diagnostically heterogeneous sample (n = 8716) that completed the UDS-NB and one of five LLTs. Construct validity was evaluated through associations with demographics, disease severity, cognitive tasks, brain volume, amyloid/tau PET positivity, and plasma phosphorylated tau. Analyses were replicated in a racially/ethnically diverse cohort (n = 839).

Results: Psychometric properties were adequate. Expected associations with demographics and clinical measures within development and validation cohorts supported validity.

Conclusions: This composite supports memory research across cohorts that administer the UDS and LLTs. A user-friendly UI is freely available to create the score in other datasets.

Keywords

Alzheimer’s Dementia and Related Disorders, Co-calibration, Cognition, Harmonization, Memory, Neurodegeneration, Neuropsychology.

Published Open-Access

yes

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