A Genome-Wide association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos

Authors

Elena V Feofanova
Han Chen
Yulin Dai
Peilin Jia
Megan L Grove
Alanna C Morrison
Qibin Qi
Martha Daviglus
Jianwen Cai
Kari E North
Cathy C Laurie
Robert C Kaplan
Eric Boerwinkle
Bing Yu

Publication Date

11-5-2020

Journal

American Journal of Human Genetics

Abstract

Variation in levels of the human metabolome reflect changes in homeostasis, providing a window into health and disease. The genetic impact on circulating metabolites in Hispanics, a population with high cardiometabolic disease burden, is largely unknown. We conducted genome-wide association analyses on 640 circulating metabolites in 3,926 Hispanic Community Health Study/Study of Latinos participants. The estimated heritability for 640 metabolites ranged between 0%-54% with a median at 2.5%. We discovered 46 variant-metabolite pairs (p value < 1.2 × 10

Keywords

Adult, Chromans, Cohort Studies, Coronary Disease, Cytochrome P450 Family 4, Diabetes Mellitus, Type 2, Female, Gene Expression, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Hispanic or Latino, Humans, Male, Membrane Transport Proteins, Metabolome, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Propionates, Public Health, Quantitative Trait Loci, Quantitative Trait, Heritable, Vitamin E