Diet, Weight Management, Physical activity and Ovarian & Breast Cancer Risk in Women With BRCA1/2 Pathogenic Germline Gene Variants: Systematic Review

Authors

Adriana M Coletta
Susan K Peterson
Leticia A Gatus
Kate J Krause
Susan M Schembre
Susan C Gilchrist
Banu Arun
Y Nancy You
Miguel A Rodriguez-Bigas
Larkin L Strong
Karen H Lu
Karen Basen-Engquist

Publication Date

1-1-2020

Journal

Hereditary Cancer in Clinical Practice

Abstract

INTRODUCTION: Women with pathogenic germline gene variants in

METHODS: We searched Medline, EMBASE, CENTRAL, PubMed, and clinicaltrials.gov up to October 3, 2019. We identified 2775 records and included 21.

RESULTS: There is limited evidence related to these factors and ovarian cancer risk. For breast cancer risk, evidence suggests higher diet quality, adulthood weight-loss of ≥10 pounds, and activity during adolescence and young-adulthood may be linked with decreased risk. Higher meat intake and higher daily energy intake may be linked with increased risk.

CONCLUSIONS: There is not enough evidence to suggest tailored recommendations for dietary habits or weight management among women with

Keywords

BRCA, Breast Cancer, Ovarian Cancer, Diet, Physical activity, Weight

DOI

10.1186/s13053-020-0137-1

PMID

32165993

PMCID

PMC7060535

PubMedCentral® Posted Date

March 2020

PubMedCentral® Full Text Version

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