Faculty, Staff and Student Publications
Language
English
Publication Date
6-1-2024
Journal
Diabetes Care
DOI
10.2337/dc23-2274
PMID
38652672
PMCID
PMC11116923
PubMedCentral® Posted Date
4-23-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Objective: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D).
Research design and methods: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD.
Results: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18.2%). We identified three novel genetic loci for incident CVD: rs147138607 (near CACNA1E/ZNF648, hazard ratio [HR] 1.23, P = 3.6 × 10-9), rs77142250 (near HS3ST1, HR 1.89, P = 9.9 × 10-9), and rs335407 (near TFB1M/NOX3, HR 1.25, P = 1.5 × 10-8). Among 204 known CAD loci, 5 were associated with incident CVD in T2D (multiple comparison-adjusted P < 0.00024, 0.05/204). A standardized polygenic score of these 204 variants was associated with incident CVD with HR 1.14 (P = 1.0 × 10-16).
Conclusions: The data point to novel and known genomic regions associated with incident CVD among individuals with T2D.
Keywords
Humans, Diabetes Mellitus, Type 2, Genome-Wide Association Study, Cardiovascular Diseases, Female, Male, Middle Aged, Aged, Polymorphism, Single Nucleotide
Published Open-Access
yes
Recommended Citation
Kwak, Soo Heon; Hernandez-Cancela, Ryan B; DiCorpo, Daniel A; et al., "Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes" (2024). Faculty, Staff and Student Publications. 446.
https://digitalcommons.library.tmc.edu/uthsph_docs/446
Included in
Endocrine System Diseases Commons, Endocrinology, Diabetes, and Metabolism Commons, Public Health Commons