Language
English
Publication Date
6-1-2024
Journal
Cell Oncology
DOI
10.1007/s13402-023-00909-3
PMID
38170381
PMCID
PMC12973970
PubMedCentral® Posted Date
1-3-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Background: Natural killer (NK) cells have gained considerable attention and hold great potential for their application in tumor immunotherapy. This is mainly due to their MHC-unrestricted and pan-specific recognition capabilities, as well as their ability to rapidly respond to and eliminate target cells. To artificially generate therapeutic NK cells, various materials can be utilized, such as peripheral blood mononuclear cells (PBMCs), umbilical cord blood (UCB), induced pluripotent stem cells (iPSCs), and NK cell lines. Exploiting the therapeutic potential of NK cells to treat tumors through in vivo and in vitro therapeutic modalities has yielded positive therapeutic results.
Conclusion: This review provides a comprehensive description of NK cell therapeutic approaches for tumors and discusses the current problems associated with these therapeutic approaches and the prospects of NK cell therapy for tumors.
Keywords
Humans, Killer Cells, Natural, Neoplasms, Immunotherapy, Animals, Cancer immunotherapy, Natural killer cell, Immune checkpoint, Chimeric antigen receptor, Memory-like, Extracellular vesicles, Oncolytic virus
Published Open-Access
yes
Recommended Citation
Huang, Mao; Liu, Yixuan; Yan, Qijia; et al., "NK Cells As Powerful Therapeutic Tool in Cancer Immunotherapy" (2024). Faculty, Staff and Students Publications. 6948.
https://digitalcommons.library.tmc.edu/baylor_docs/6948