Skin in the Game: A Review of Single-Cell and Spatial Transcriptomics in Dermatological Research

Authors

Samuel Schepps
Jonathan Xu
Henry Yang
Jenna Mandel
Jaanvi Mehta
Julianna Tolotta
Nicole Baker
Volkan Tekmen
Neda Nikbakht
Paolo Fortina
Ignacia Fuentes
Bonnie LaFleur
Raymond J Cho
Andrew P South

Language

English

Publication Date

9-25-2024

Journal

Clinical Chemistry and Laboratory Medicine

DOI

10.1515/cclm-2023-1245

PMID

38656304

Abstract

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging research technologies that uniquely characterize gene expression microenvironments on a cellular or subcellular level. The skin, a clinically accessible tissue composed of diverse, essential cell populations, serves as an ideal target for these high-resolution investigative approaches. Using these tools, researchers are assembling a compendium of data and discoveries in healthy skin as well as a range of dermatologic pathophysiologies, including atopic dermatitis, psoriasis, and cutaneous malignancies. The ongoing advancement of single-cell approaches, coupled with anticipated decreases in cost with increased adoption, will reshape dermatologic research, profoundly influencing disease characterization, prognosis, and ultimately clinical practice.

Keywords

Humans, Single-Cell Analysis, Skin, Transcriptome, Gene Expression Profiling, Skin Diseases, Dermatology, Sequence Analysis, RNA, gene expression, single cell transcriptomics, skin, spatial transcriptomics.

Published Open-Access

no

Recommended Citation

Schepps, Samuel; Xu, Jonathan; Yang, Henry; et al., "Skin in the Game: A Review of Single-Cell and Spatial Transcriptomics in Dermatological Research" (2024). Staff and Researcher Publications. 31.
https://digitalcommons.library.tmc.edu/clinic_pub/31