Language
English
Publication Date
5-14-2025
Journal
Biochemical Journal
DOI
10.1042/BCJ20253103
PMID
40364616
PMCID
PMC12203960
PubMedCentral® Posted Date
5-14-2025
PubMedCentral® Full Text Version
Post-print
Abstract
3',5'-cyclic adenosine monophosphate (cAMP) is a fundamental secondary messenger capable of rapidly amplifying and propagating cellular signals in response to various extracellular stimuli. cAMP plays a significant role in hormone-mediated regulation of renal fluid and electrolyte balance. Impaired signaling of cAMP has been linked to a variety of pathological ramifications in the kidneys. This review explores the physiological functions of exchange proteins directly activated by cAMP (Epac) in renal water balance and the regulation of solute transport in the renal tubule. Additionally, the involvement of Epac signaling in renal pathologies such as acute kidney injury, chronic kidney disease, and polycystic kidney disease is discussed.
Keywords
Humans, Guanine Nucleotide Exchange Factors, Animals, Cyclic AMP, Signal Transduction, Kidney, Acute Kidney Injury, Water-Electrolyte Balance, aquaporin (AQP), electrolyte transport, epithelial Na+channel (ENaC), Na+/H+exchanger type 3 (NHE-3), polyuria
Published Open-Access
yes
Recommended Citation
Oleh Pochynyuk, Kyrylo Pyrshev, and Xiaodong Cheng, "Multifaceted Roles of Epac Signaling in Renal Functions" (2025). The Brown Foundation: Institute of Molecular Medicine. 21.
https://digitalcommons.library.tmc.edu/molecular_med/21