Language
English
Publication Date
1-1-2025
Journal
Lifestyle Genomics
DOI
10.1159/000546100
PMID
40451158
PMCID
PMC12235720
PubMedCentral® Posted Date
5-30-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
Introduction: Prior work in predominantly European ancestry populations has explained how the risk associated with demographic, lifestyle, and health factors differs with underlying genetic susceptibility to type 2 diabetes (T2D), but less is known about these relationships in Black Americans.
Methods: We used covariate-adjusted logistic regression models of T2D to examine interactions between a published trans-ancestry derived T2D polygenic risk score (PRS) and various demographic, lifestyle, and health-related factors among 28,251 self-identified Black Americans from six cohort studies.
Results: The results are generally consistent with prior work in White populations. The PRS showed a significant interaction with body mass index, with a greater effect on T2D risk in individuals who were leaner (pinteraction = 0.038).
Conclusion: These results contribute to understanding the relationship between genetics and other T2D risk factors in Black Americans who have a high burden of T2D, potentially informing targeted prevention strategies.
Keywords
Adult, Aged, Female, Humans, Male, Middle Aged, Black or African American, Body Mass Index, Cohort Studies, Diabetes Mellitus, Type 2, Genetic Risk Score, Life Style, Logistic Models, Multifactorial Inheritance, Body mass index, Diabetes, Epidemiology, Lifestyle interactions, Polygenic risk scores
Published Open-Access
yes
Recommended Citation
Scadden, Ashley W; Kakar, Aastha; Litkowski, Elizabeth M; et al., "Type 2 Diabetes Polygenic Risk Score Interactions with Lifestyle Risk Factors in Black Americans" (2025). The Brown Foundation: Institute of Molecular Medicine. 30.
https://digitalcommons.library.tmc.edu/molecular_med/30