Language
English
Publication Date
4-1-2025
Journal
Critical Reviews in Oncology/Hematology
DOI
10.1016/j.critrevonc.2025.104632
PMID
39864535
PMCID
PMC12910606
PubMedCentral® Posted Date
2-18-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
Physiological processes such as the sleep-wake cycle, metabolism, hormone secretion, neurotransmitter release, sensory capabilities, and a variety of behaviors, including sleep, are controlled by a circadian rhythm adapted to 24-hour day-night periodicity. Disruption of circadian rhythm may lead to the risks of numerous diseases, including cancers. Several epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer. On the contrary, oncogenic processes may suppress the homeostatic balance imposed by the circadian clock. The integration of circadian biology into cancer research offers new options for making cancer treatment more effective, and the pharmacological modulation of core clock genes is a new approach in cancer therapy. This review highlights the role of the circadian clock in tumorigenesis, how clock disruption alters the tumor microenvironment, and discusses how pharmacological modulation of circadian clock genes can lead to new therapeutic options.
Keywords
Humans, Neoplasms, Circadian Clocks, Circadian Rhythm, Animals, Tumor Microenvironment, Circadian rhythm, Circadian disruption, Tumor, Clock genes, Tumor microenvironment, Circulatory tumor cells, Chronotherapy, Tumor metabolism
Published Open-Access
yes
Recommended Citation
Ogunlusi, Olajumoke; Ghosh, Abantika; Sarkar, Mrinmoy; et al., "Rhythm Is Essential: Unraveling the Relation Between the Circadian Clock and Cancer" (2025). The Brown Foundation: Institute of Molecular Medicine. 54.
https://digitalcommons.library.tmc.edu/molecular_med/54