Language
English
Publication Date
3-23-2026
Journal
The Journal for ImmunoTherapy of Cancer
DOI
10.1136/jitc-2025-013668
PMID
41871873
Abstract
γδ T cells are unconventional lymphocytes that bridge innate and adaptive immunity by combining recognition of stress-induced ligands independently of classical major histocompatibility complex molecules with the capacity to undergo clonal expansion and long-term adaptation. Their unusual ability to detect malignant transformation using semi-invariant T-cell receptors, butyrophilin recognition and natural killer-like receptors positions them as powerful effector cells in tumors that evade classical immune escape mechanisms. Furthermore, distinct γδ subsets have distinct phenotyping and specific tissue-residencies, which could be leveraged to modulate immunological responses. We evaluate engineered therapies and different experimental platforms for studying γδ T cell biology. We conclude that next-generation cancer treatments should strategically integrate γδ T cells into synthetic immunology, individualized modeling, and combinatorial regimes.
Keywords
Humans, Immunity, Innate, Adaptive Immunity, Neoplasms, Receptors, Antigen, T-Cell, gamma-delta, Animals, T-Lymphocytes, Adaptive, Education, Immunotherapy, Innate, T-Lymphocytes
Published Open-Access
yes
Recommended Citation
Solé Casaramona, Arnau; Bachmann, Martin F; Sevick-Muraca, Eva; et al., "γδ T Cells at the Interface of Innate and Adaptive Immunity in Cancer" (2026). The Brown Foundation: Institute of Molecular Medicine. 72.
https://digitalcommons.library.tmc.edu/molecular_med/72