Language
English
Publication Date
6-1-2025
Journal
International Forum of Allergy & Rhinology
DOI
10.1002/alr.23582
PMID
40310935
PMCID
PMC12645459
PubMedCentral® Posted Date
11-26-2025
PubMedCentral® Full Text Version
Author MSS
Abstract
Allergic fungal rhinosinusitis (AFRS) is a unique endotype of chronic rhinosinusitis with nasal polyps (CRSwNP). Despite high recurrence rates and often more severe presenting signs compared with other subtypes of CRSwNP, research dedicated to AFRS has been lacking. Diagnostic criteria are outdated, the mechanistic relationship of AFRS to other associated diseases is unclear, and the pathophysiology of disease and risk factors for recurrence have not been well studied. In December 2023, a multidisciplinary group of rhinologists, otolaryngologists, pulmonologists, allergists, immunologists, scientists, and infectious disease experts met at the National Institute of Health to discuss unmet needs for future AFRS research and care, including patient management, diagnostic criteria, severity, pathophysiology, and related conditions. A summary of these clinical and associated research discussions is included below.
Keywords
Humans, Sinusitis, Mycoses, Rhinitis, Allergic, Nasal Polyps, Chronic Disease, Allergic Fungal Sinusitis, allergic sinusitis, allergic fungal sinusitis, chronic rhinosinusitis, fungal sinusitis, invasive fungal sinusitis, nasal polyps
Published Open-Access
yes
Recommended Citation
Roland, Lauren T; Damask, Cecelia; Luong, Amber U; et al., "Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop" (2025). The Brown Foundation: Institute of Molecular Medicine. 73.
https://digitalcommons.library.tmc.edu/molecular_med/73