Faculty, Staff and Student Publications
Publication Date
7-11-2023
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abstract
Epithelial-to-mesenchymal transition (EMT) underlies immunosuppression, drug resistance, and metastasis in epithelial malignancies. However, the way in which EMT orchestrates disparate biological processes remains unclear. Here, we identify an EMT-activated vesicular trafficking network that coordinates promigratory focal adhesion dynamics with an immunosuppressive secretory program in lung adenocarcinoma (LUAD). The EMT-activating transcription factor ZEB1 drives exocytotic vesicular trafficking by relieving Rab6A, Rab8A, and guanine nucleotide exchange factors from miR-148a-dependent silencing, thereby facilitating MMP14-dependent focal adhesion turnover in LUAD cells and autotaxin-mediated CD8
Keywords
Humans, Cell Line, Tumor, Zinc Finger E-box-Binding Homeobox 1, Lung Neoplasms, Adenocarcinoma of Lung, MicroRNAs, Immunosuppression Therapy, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Cell Movement
DOI
10.1073/pnas.2220276120
PMID
37406091
PMCID
PMC10334751
PubMedCentral® Posted Date
July 2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons, Pulmonology Commons, Respiratory Tract Diseases Commons
Comments
Supplementary Material
PMID: 37406091