Faculty, Staff and Student Publications

Publication Date

7-11-2023

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abstract

Epithelial-to-mesenchymal transition (EMT) underlies immunosuppression, drug resistance, and metastasis in epithelial malignancies. However, the way in which EMT orchestrates disparate biological processes remains unclear. Here, we identify an EMT-activated vesicular trafficking network that coordinates promigratory focal adhesion dynamics with an immunosuppressive secretory program in lung adenocarcinoma (LUAD). The EMT-activating transcription factor ZEB1 drives exocytotic vesicular trafficking by relieving Rab6A, Rab8A, and guanine nucleotide exchange factors from miR-148a-dependent silencing, thereby facilitating MMP14-dependent focal adhesion turnover in LUAD cells and autotaxin-mediated CD8

Keywords

Humans, Cell Line, Tumor, Zinc Finger E-box-Binding Homeobox 1, Lung Neoplasms, Adenocarcinoma of Lung, MicroRNAs, Immunosuppression Therapy, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Cell Movement

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