Faculty, Staff and Student Publications
Publication Date
10-7-2023
Journal
Brain Sciences
Abstract
Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.
Keywords
optic pathway glioma, optic nerve, neurofibromatosis type 1, tumor microenvironment, cancer neuroscience, tumor-associated microglia and macrophages, T cells
DOI
10.3390/brainsci13101424
PMID
37891793
PMCID
PMC10605541
PubMedCentral® Posted Date
October 2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Biomedical Informatics Commons, Eye Diseases Commons, Neurosciences Commons, Oncology Commons, Ophthalmology Commons