Faculty, Staff and Student Publications
Publication Date
9-19-2023
Journal
Cell Reports Medicine
Abstract
Emerging evidence implicates microbiome involvement in the development of pancreatic cancer (PaCa). Here, we investigate whether increases in circulating microbial-related metabolites associate with PaCa risk by applying metabolomics profiling to 172 sera collected within 5 years prior to PaCa diagnosis and 863 matched non-subject sera from participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) cohort. We develop a three-marker microbial-related metabolite panel to assess 5-year risk of PaCa. The addition of five non-microbial metabolites further improves 5-year risk prediction of PaCa. The combined metabolite panel complements CA19-9, and individuals with a combined metabolite panel + CA19-9 score in the top 2.5th percentile have absolute 5-year risk estimates of >13%. The risk prediction model based on circulating microbial and non-microbial metabolites provides a potential tool to identify individuals at high risk of PaCa that would benefit from surveillance and/or from potential cancer interception strategies.
Keywords
Male, Humans, CA-19-9 Antigen, Pancreatic Neoplasms, Pancreas, Metabolomics, microbiome, metabolites, biomarker, risk assessment, pancreatic cancer
DOI
10.1016/j.xcrm.2023.101194
PMID
37729870
PMCID
PMC10518621
PubMedCentral® Posted Date
September 2023
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Digestive System Diseases Commons, Gastroenterology Commons, Medical Sciences Commons, Neoplasms Commons, Oncology Commons