The Mechanisms of Action of Tumor Treating Fields

Authors

Justin C Moser
Ellaine Salvador
Karina Deniz
Kenneth Swanson
Jack Tuszynski
Kristen W Carlson
Narasimha Kumar Karanam
Chirag B Patel
Michael Story
Emil Lou
Carsten Hagemann

Publication Date

10-17-2022

Journal

Cancer Research

DOI

10.1158/0008-5472.CAN-22-0887

PMID

35839284

PMCID

PMC9574373

PubMedCentral® Posted Date

July 2022

PubMedCentral® Full Text Version

Post-print

Abstract

Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action.

Keywords

Antimitotic Agents, Brain Neoplasms, Electric Stimulation Therapy, Glioblastoma, Humans

Published Open-Access

yes

Recommended Citation

Moser, Justin C; Salvador, Ellaine; Deniz, Karina; et al., "The Mechanisms of Action of Tumor Treating Fields" (2022). Faculty, Staff and Student Publications. 1866.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/1866