Ablation of the Integrin CD11b Mac-1 Limits Deleterious Responses to Traumatic Spinal Cord Injury and Improves Functional Recovery in Mice

Authors

Yun Li
Zhuofan Lei
Rodney M Ritzel
Junyun He
Simon Liu
Li Zhang
Junfang Wu

Publication Date

9-20-2024

Journal

Cells

Abstract

Spinal cord injury (SCI) triggers microglial/monocytes activation with distinct pro-inflammatory or inflammation-resolving phenotypes, which potentiate tissue damage or facilitate functional repair, respectively. The major integrin Mac-1 (CD11b/CD18), a heterodimer consisting of CD11b and CD18 chains, is expressed in multiple immune cells of the myeloid lineage. Here, we examined the effects of CD11b gene ablation in neuroinflammation and functional outcomes after SCI. qPCR analysis of C57BL/6 female mice showed upregulation of

Keywords

Animals, Female, Mice, CD11b Antigen, Disease Models, Animal, Inflammation, Macrophage-1 Antigen, Mice, Inbred C57BL, Mice, Knockout, Microglia, Recovery of Function, Spinal Cord Injuries

Comments

Supplementary Materials

Data Availability Statement

PMID: 39329765

DOI

10.3390/cells13181584

PMID

39329765

PMCID

PMC11430243

PubMedCentral® Posted Date

September 2024

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes