Faculty, Staff and Student Publications
Publication Date
1-1-2023
Journal
OncoImmunology
DOI
10.1080/2162402X.2023.2275333
PMID
37937212
PMCID
PMC10627057
PubMedCentral® Posted Date
November 2023
PubMedCentral® Full Text Version
Post-print
Abstract
Radiation therapy and anti-CTLA-4 combination therapy can induce meaningful responses in some patients. Adding CD40 may provide additional benefit. Next-generation anti-CTLA-4 antibodies, such as botensilimab, are showing promise in clinical trials. Combining botensilimab with RT and/or CD40 agonist may offer additional benefits for challenging tumor types.
Keywords
Clinical trials, CTLA-4 blockade, immune checkpoint blockade, next generation immunotherapy, radiation therapy
Published Open-Access
yes
Recommended Citation
Nils-Petter Rudqvist, Manushak Avagyan, and Dhan Chand, "Next-Generation Ctla-4 Targeting Molecules and Combination Therapy: Promising Strategies for Improving Cancer Immunotherapy" (2023). Faculty, Staff and Student Publications. 1942.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/1942
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