Induction of Thrombotic Thrombocytopenic Purpura by Dengue Virus Infection in a Critical Patient: Role of Therapeutic Plasma Exchange

Authors

Rathindra Nath Biswas
Sudipta Sekhar Das
Anupam Chakrapani
Subrata Sen

Publication Date

1-1-2023

Journal

Asian Journal of Transfusion Science

Abstract

Thrombotic thrombocytopenic purpura (TTP) secondary to dengue fever is a very unusual occurrence. Both conditions are fatal and can result in significant mortality and morbidity if left untreated. In this case, we present a young lady who suffered dengue fever followed by microangiopathic anemia, thrombocytopenic purpura, and altered sensorium. Investigations revealed microangiopathic hemolysis; there was no evidence of disseminated intravascular coagulation. As soon as, we diagnosed the patient as having TTP, we treated her with serial plasma exchange therapy, steroids, and monoclonal antibodies such as rituximab. The patient responded very well to the treatment and completely recovered from neurological symptoms and laboratory parameters also normalized. Hence, timely diagnosis and starting appropriate treatment immediately are key factors for successful outcomes.

Keywords

Dengue, therapeutic plasma exchanges, thrombotic thrombocytopenic purpura

Comments

PMID: 38274960