Plasmonic Gadolinium Oxide Nanomatryoshkas: Bifunctional Magnetic Resonance Imaging Enhancers for Photothermal Cancer Therapy

Authors

Luke Henderson
Oara Neumann
Yara Kadria-Vili
Burak Gerislioglu
James Bankson
Peter Nordlander
Naomi J Halas

Publication Date

9-1-2022

Journal

PNAS Nexus

Abstract

Nanoparticle-assisted laser-induced photothermal therapy (PTT) is a promising method for cancer treatment; yet, visualization of nanoparticle uptake and photothermal response remain a critical challenge. Here, we report a magnetic resonance imaging-active nanomatryoshka (Gd2O3-NM), a multilayered (Au core/Gd2O3 shell/Au shell) sub-100 nm nanoparticle capable of combining T1 MRI contrast with PTT. This bifunctional nanoparticle demonstrates an r1 of 1.28 × 108 mM-1 s-1, an MRI contrast enhancement per nanoparticle sufficient for T1 imaging in addition to tumor ablation. Gd2O3-NM also shows excellent stability in an acidic environment, retaining 99% of the internal Gd(3). This report details the synthesis and characterization of a promising system for combined theranostic nanoparticle tracking and PTT.

Keywords

nanomatryoshka, MRI contrast agents, gadolinium, gadolinium oxide, photothermal cancer therapy

Comments

Supplementary Materials

PMID: 36714874