Precision Dosimetry in Yttrium-90 Radioembolization Through Ct Imaging of Radiopaque Microspheres in a Rabbit Liver Model

Authors

E Courtney Henry
Matthew Strugari
George Mawko
Kimberly Brewer
David Liu
Andrew C Gordon
Jeffrey N Bryan
Charles Maitz
James J Karnia
Robert Abraham
S Cheenu Kappadath
Alasdair Syme

Publication Date

3-21-2022

Journal

EJNMMI Physics

DOI

10.1186/s40658-022-00447-1

PMID

35312882

PMCID

PMC8938593

PubMedCentral® Posted Date

3-21-2022

PubMedCentral® Full Text Version

Post-print

Abstract

Purpose: To perform precision dosimetry in yttrium-90 radioembolization through CT imaging of radiopaque microspheres in a rabbit liver model and to compare extracted dose metrics to those produced from conventional PET-based dosimetry.

Materials and methods: A CT calibration phantom was designed containing posts with nominal microsphere concentrations of 0.5 mg/mL, 5.0 mg/mL, and 25.0 mg/mL. The mean Hounsfield unit was extracted from the post volumes to generate a calibration curve to relate Hounsfield units to microsphere concentration. A nominal bolus of 40 mg of microspheres was administered to the livers of eight rabbits, followed by PET/CT imaging. A CT-based activity distribution was calculated through the application of the calibration curve to the CT liver volume. Post-treatment dosimetry was performed through the convolution of yttrium-90 dose-voxel kernels and the PET- and CT-based cumulated activity distributions. The mean dose to the liver in PET- and CT-based dose distributions was compared through linear regression, ANOVA, and Bland-Altman analysis.

Results: A linear least-squares fit to the average Hounsfield unit and microsphere concentration data from the calibration phantom confirmed a strong correlation (r2 > 0.999) with a slope of 14.13 HU/mg/mL. A poor correlation was found between the mean dose derived from CT and PET (r2 = 0.374), while the ANOVA analysis revealed statistically significant differences (p < 10-12) between the MIRD-derived mean dose and the PET- and CT-derived mean dose. Bland-Altman analysis predicted an offset of 15.0 Gy between the mean dose in CT and PET. The dose within the liver was shown to be more heterogeneous in CT than in PET with an average coefficient of variation equal to 1.99 and 1.02, respectively.

Conclusion: The benefits of a CT-based approach to post-treatment dosimetry in yttrium-90 radioembolization include improved visualization of the dose distribution, reduced partial volume effects, a better representation of dose heterogeneity, and the mitigation of respiratory motion effects. Post-treatment CT imaging of radiopaque microspheres in yttrium-90 radioembolization provides the means to perform precision dosimetry and extract accurate dose metrics used to refine the understanding of the dose-response relationship, which could ultimately improve future patient outcomes.

Keywords

CT, Dosimetry, Microsphere, PET, Radioembolization, Radiopacity, Yttrium-90

Comments

This article has been corrected. See EJNMMI Phys. 2023 Nov 29;10:74.

Published Open-Access

yes

Recommended Citation

Henry, E Courtney; Strugari, Matthew; Mawko, George; et al., "Precision Dosimetry in Yttrium-90 Radioembolization Through Ct Imaging of Radiopaque Microspheres in a Rabbit Liver Model" (2022). Faculty, Staff and Student Publications. 4559.
https://digitalcommons.library.tmc.edu/uthgsbs_docs/4559