Publication Date
6-1-2023
Journal
Cancer Research Communications
Abstract
UNLABELLED: Triple-negative breast cancer (TNBC) has high relapse and metastasis rates and a high proportion of cancer stem-like cells (CSC), which possess self-renewal and tumor initiation capacity. MELK (maternal embryonic leucine zipper kinase), a protein kinase of the Snf1/AMPK kinase family, is known to promote CSC maintenance and malignant transformation. However, the role of MELK in TNBC metastasis is unknown; we sought to address this in the current study. We found that
SIGNIFICANCE: These findings indicate that MELK is a driver of aggressiveness and metastasis in TNBC.
Keywords
Humans, Animals, Mice, Triple Negative Breast Neoplasms, Mice, Nude, Leucine Zippers, Cell Proliferation, Neoplasm Recurrence, Local, Protein Serine-Threonine Kinases
Included in
Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons
Comments
This article has been corrected. See Cancer Res Commun. 2024 January; 4(1): 236.
Supplementary Materials
PMID: 37377604