Faculty, Staff and Student Publications
Publication Date
9-17-2024
Journal
Cell Reports Medicine
Abstract
Pancreatic cancer is associated with an oncogenic KRAS mutation in approximately 90% of cases. However, a non-negligible proportion of pancreatic cancer cases harbor wild-type KRAS (KRAS-WT). This study establishes genetically engineered mouse models that develop spontaneous pancreatic cancer in the context of KRAS-WT. The Trp53
Keywords
Smad4 Protein, Animals, Pancreatic Neoplasms, Tumor Suppressor Protein p53, Proto-Oncogene Proteins p21(ras), Mutation, Mice, Humans, Carcinoma, Adenosquamous, Disease Models, Animal, Receptor, Transforming Growth Factor-beta Type II, pancreatic ductal adenocarcinoma, pancreatic adenosquamous carcinoma, single-cell RNA-sequencing analysis, genetically engineered mouse models, tumor microenvironment
Graphical Abstract
Included in
Bioinformatics Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Biomedical Informatics Commons, Medical Cell Biology Commons, Oncology Commons
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Associated Data
PMID: 39232498