Faculty, Staff and Student Publications

Publication Date

5-31-2024

Journal

Science Advances

DOI

10.1126/sciadv.adk3121

PMID

38809988

PMCID

PMC11135391

PubMedCentral® Posted Date

5-29-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit

Keywords

Humans, Colorectal Neoplasms, Anti-Inflammatory Agents, Non-Steroidal, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Aspirin, Receptors, Prostaglandin E, EP4 Subtype, Male, Genetic Predisposition to Disease, Female, Case-Control Studies, Middle Aged, Genetic Loci, Aged

Published Open-Access

yes

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